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Practice Guidelines in Oncology: Breast Cancer. National Comprehensive Cancer Network (NCCN). Philadelphia, Pa: Lippincott Williams & Wilkins 2019. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. In: DeVita VT, Lawrence TS, Lawrence TS, Rosenberg SA, eds. Chapter 79: Malignant Tumors of the Breast. Jagsi R, King TA, Lehman C, Morrow M, Harris JR, Burstein HJ. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Henry NL, Shah PD, Haider I, Freer PE, Jagsi R, Sabel MS. These cancers are treated with hormone drugs as well as drugs that target HER2. Triple-positive breast tumors are HER2-positive, ER-positive, and PR-positive. See Triple-negative Breast Cancer to learn more. Hormone therapy and drugs that target HER2 are not helpful in treating these cancers. Triple-negative breast tumors don’t have too much HER2 and also don’t have estrogen or progesterone receptors.
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If the IHC result is 2+, the HER2 status of the tumor is not clear and is called " equivocal." This means that the HER2 status needs to be tested with FISH to clarify the result.These cancers are usually treated with drugs that target HER2. If the IHC result is 3+, the cancer is HER2-positive.These cancers do not respond to treatment with drugs that target HER2. If the IHC result is 0 or 1+, the cancer is considered HER2-negative.It is not clear if one test is more accurate than the other, but FISH is more expensive and takes longer to get the results. Often the IHC test is done first. The results of HER2 testing will guide you and your cancer care team in making the best treatment decisions. See Testing Biopsy and Cytology Specimens for Cancer and Understanding Your Pathology Report: Breast Cancer to get more details about these tests. How are breast tumors tested for HER2?Įither a test called an immunohistochemistry (IHC) test or fluorescence in situ hybridization (F ISH) test is used to find out if cancer cells have a high level of the HER2 protein. These cancers tend to grow and spread faster than breast cancers that are HER2-negative, but are much more likely to respond to treatment with drugs that target the HER2 protein.Īll invasive breast cancers should be tested for HER2 either on the biopsy sample or when the tumor is removed with surgery. Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. HER2 is a protein that helps breast cancer cells grow quickly. Ask your doctor about your HER2 status and what it means for you. These cancers are called HER2-positive breast cancers. Of breast tumors have higher levels of a protein known as HER2.